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Heather Bradshaw
Assistant Research Scientist
The Kinsey Institute
Assistant Professor
The Department of Psychological & Brain Sciences
Morrison Hall 313
Indiana University
Bloomington, IN 47405
Phone: (812) 855-7686
E-mail: hbbradsh at indiana dot edu
Webpage(s): Walker Lab
CV:
Dr. Heather Bradshaw
Education
Ph.D., Florida State University, 2001
B.S. Florida State University, 1994
Research Statement

During Dr. Bradshaw's graduate career, she studied behavioral responses to uterine and vaginal stimulation in rats in concert with neurophysiologic measurements in the brainstem in order to understand neuronal responses to stimulation of reproductive tissue. These studies identified novel processing of neuronal information from stimulation of the uterus, cervix, and vagina in the brain and showed that both the behavioral and neuronal responses changed with variations in circulating hormones.

To further understand neuronal processing at the cellular level she pursued post-doctoral training at Brown University in the field of endogenous cannabinoid lipid signaling. Her studies in this field led to a post-doctoral grant to study the relationship of endogenous cannabinoids and uterine neurophysiology. During these studies she moved with her post-doctoral mentor to the Indiana University Department of Psychological and Brain Sciences. Her current work focuses on the regulation of uterine contractions by endogenous cannabinoid signaling lipids.

Dr. Bradshaw's focus at the Kinsey Institute will be to more fully understand how different chronic conditions in humans are perhaps caused by the loss of the regulation of uterine and vaginal neurophysiology. There are very little data on vaginal neurophysiology in particular in humans and that is something she would like to work on within the Kinsey Institute. By crossing-over into human studies of the regulation of vaginal smooth muscle tone, Dr. Bradshaw's goal is to provide a better framework for understanding chronic conditions involving vaginal function.

Research Interests
  • endogenous cannabinoids and uterine neurophysiology
  • vaginal neurophysiology
  • role of hormones in neural response
  • chemical signaling mechanisms
Selected Honors
Ruth L. Kirschstein National Research Service Award Post-doctoral Fellowship, 2003-2007
Florida State University Neuroscience Pre-doctoral Fellowship, May 1996-Dec 2000
Selected Publications
Bradshaw, H.B. and Walker, J.M. (2005). The expanding field of cannabimimetic and related lipid mediators. British Journal of Pharmacology, 144, 459-65. Review.
Fernandez-Rodriguez, C.M., Romero, J., Petros, T.J., Bradshaw, H., Gasalla, J.M., Gutierrez, M.L., Lledo, J.L., Santander, C., Fernandez, T.P., Tomas, E., Cacho, G., Walker, J.M. (2004). Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis. Liver International, 24, 477-83.
Bradshaw, H.B. and Berkley, K.J. (2003). The influence of ovariectomy with or without estrogen replacement on responses of rat gracile nucleus neurons to stimulation of hindquarter skin and pelvic viscera. Brain Research, 986 , 82-90.
Bradshaw, H.B. and Berkley, K.J. (2002). Estrogen Replacement Reverses Ovariectomy-Induced Vaginal Hyperalgesia in the Rat. Maturitas, 41, 157-165.
Berkley, K.J., Cason, A., Jacobs, H., Bradshaw, H., Wood, E. (2001). Vaginal hyperalgesia in a rat model of endometriosis. Neuroscience Letters, 306, 185-8.
Bradshaw, H.B. and Berkley, K.J. (2000). Estrous Changes in Responses of Rat Gracile Nucleus Neurons to Stimulation of Skin and Pelvic Viscera. Journal of Neuroscience, 20, 7722-7727.

For a full list of Kinsey Institute research publications, with selected .pdf files, please visit our Kinsey Institute Staff Publications page.


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